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Targeted Allele Detail
Symbol: Mapk1tm1a(EUCOMM)Wtsi
Name: mitogen-activated protein kinase 1; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4432537
Gene: Mapk1  Location: Chr16:16983382-17047453 bp, + strand  Genetic Position: Chr16, 10.53 cM
Mutant Cell Lines:  EPD0065_1_A04, EPD0065_1_A05, EPD0065_1_A06, EPD0065_1_B06, EPD0065_1_C04, EPD0065_1_C05, EPD0065_1_C06, EPD0065_1_D04, EPD0065_1_D05, EPD0065_1_D06, EPD0065_1_E04, EPD0065_1_E06, EPD0065_1_F04, EPD0065_1_F06, EPD0065_1_G04, EPD0065_1_H05, EPD0065_1_H06 (Wellcome Trust Sanger Institute)
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt2
Mutation detailsThe L1L2_gt2 cassette was inserted at position 17017859 of Chromosome 16 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 17018720. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/aboutkompstrategies. (J:155845, J:173534)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk1 Mutation:  24 strains or lines available
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory