About   Help   FAQ
Rpgrip1ltm1a(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Rpgrip1ltm1a(EUCOMM)Wtsi
Name: Rpgrip1-like; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4432510
Gene: Rpgrip1l  Location: Chr8:91217030-91313262 bp, - strand  Genetic Position: Chr8, 44.29 cM
Mutation
origin
Mutant Cell Lines:  EPD0373_5_A01, EPD0373_5_A02, EPD0373_5_A04, EPD0373_5_A05, EPD0373_5_A11, EPD0373_5_B01, EPD0373_5_B02, EPD0373_5_B05, EPD0373_5_B09, EPD0373_5_B11, EPD0373_5_C06, EPD0373_5_C09, EPD0373_5_D03, EPD0373_5_D04, EPD0373_5_D06, EPD0373_5_D07, EPD0373_5_D12, EPD0373_5_E02, EPD0373_5_E03, EPD0373_5_E04, EPD0373_5_E07, EPD0373_5_E08, EPD0373_5_E09, EPD0373_5_E11, EPD0373_5_F02, EPD0373_5_F03, EPD0373_5_F05, EPD0373_5_G02, EPD0373_5_G04, EPD0373_5_G05, EPD0373_5_G06, EPD0373_5_G11, EPD0373_5_G12, EPD0373_5_H03, EPD0373_5_H04, EPD0373_5_H08, EPD0373_5_H09, EPD0373_5_H10, EPD0373_5_H12
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 91301330 of Chromosome 8 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 91300557. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 65 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Rpgrip1l Mutation:  31 strains or lines available
References
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/10/2019
MGI 6.14
The Jackson Laboratory