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Targeted Allele Detail
Symbol: Ints12tm1a(EUCOMM)Wtsi
Name: integrator complex subunit 12; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4432308
Gene: Ints12  Location: Chr3:133091840-133110988 bp, + strand  Genetic Position: Chr3, 61.56 cM, cytoband H2
Mutant Cell Lines:  EPD0058_2_A06, EPD0058_2_B04, EPD0058_2_B06, EPD0058_2_C06, EPD0058_2_D04, EPD0058_2_D05, EPD0058_2_E04, EPD0058_2_E05, EPD0058_2_E06, EPD0058_2_F05, EPD0058_2_F06, EPD0058_2_G04, EPD0058_2_G06, EPD0058_2_H04, EPD0058_2_H05, EPD0058_2_H06 (Wellcome Trust Sanger Institute)
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt0
Mutation detailsThe L1L2_gt0 cassette was inserted at position 133100202 of Chromosome 3 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 133101081. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/aboutkompstrategies. (J:155845, J:173534)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ints12 Mutation:  20 strains or lines available
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory