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Targeted Allele Detail
Symbol: Epc2tm1a(EUCOMM)Wtsi
Name: enhancer of polycomb homolog 2 (Drosophila); targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4431957
Gene: Epc2  Location: Chr2:49451486-49551948 bp, + strand  Genetic Position: Chr2, 28.62 cM
Mutant Cell Lines:  EPD0013_1_A09, EPD0013_1_B09, EPD0013_1_C09, EPD0013_1_D09, EPD0013_1_E09, EPD0013_1_F09, EPD0013_1_G09, EPD0018_2_A11, EPD0018_2_A12, EPD0018_2_B10, EPD0018_2_B11, EPD0018_2_B12, EPD0018_2_C10, EPD0018_2_C11, EPD0018_2_C12, EPD0018_2_D10, EPD0018_2_D11, EPD0018_2_E10, EPD0018_2_E11, EPD0018_2_E12, EPD0018_2_F10, EPD0018_2_F11, EPD0018_2_G10, EPD0018_2_G12, EPD0018_2_H10 (Wellcome Trust Sanger Institute)
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gtk
Mutation detailsThe L1L2_gtk cassette was inserted at position 49488197 of Chromosome 2 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 49489193. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/aboutkompstrategies. (J:155845, J:173534)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Epc2 Mutation:  40 strains or lines available
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory