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Targeted Allele Detail
Symbol: Ezrtm2a(EUCOMM)Wtsi
Name: ezrin; targeted mutation 2a, Wellcome Trust Sanger Institute
MGI ID: MGI:4431855
Gene: Ezr  Location: Chr17:6738131-6782780 bp, - strand  Genetic Position: Chr17, 4.38 cM
Mutant Cell Lines:  EPD0080_2_A07, EPD0080_2_A09, EPD0080_2_B09, EPD0080_2_C07, EPD0080_2_C08, EPD0080_2_C09, EPD0080_2_D08, EPD0080_2_D09, EPD0080_2_E07, EPD0080_2_E08, EPD0080_2_E09, EPD0080_2_F07, EPD0080_2_F08, EPD0080_2_F09, EPD0080_2_G07, EPD0080_2_G08, EPD0080_2_G09, EPD0080_2_H07, EPD0080_2_H08
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt2
Mutation detailsThe L1L2_gt2 cassette was inserted at position 6747781 of Chromosome 17 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 6747023. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Ezr Mutation:  59 strains or lines available
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory