Tnk2^{tm1a(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Tnk2^{tm1a(EUCOMM)Wtsi}
• Name: tyrosine kinase, non-receptor, 2; targeted mutation 1a, Wellcome Trust Sanger Institute
• MGI ID: MGI:4431790
• Gene: Tnk2 Location: Chr16:32462699-32502311 bp, + strand Genetic Position: Chr16, 23.16 cM
• IMPC: Tnk2 gene page

Mutation origin

• Mutant Cell Lines: EPD0102_3_A04, EPD0102_3_B04, EPD0102_3_C04, EPD0102_3_C06, EPD0102_3_D04, EPD0102_3_D05, EPD0102_3_E05, EPD0102_3_F05, EPD0102_3_G04, EPD0102_3_G05, EPD0102_3_H04, EPD0102_3_H05, EPD0102_3_H06
• Germline Transmission: Unknown
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt1
• Mutation details: The L1L2_gt1 cassette was inserted at position 32484214 of Chromosome 16 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 32485035. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnk2 Mutation: 60 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 2 reference(s)