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Smoc1tm1a(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Smoc1tm1a(EUCOMM)Wtsi
Name: SPARC related modular calcium binding 1; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4431709
Synonyms: Smoc1tm1a
Gene: Smoc1  Location: Chr12:81026808-81186414 bp, + strand  Genetic Position: Chr12, 37.28 cM
Ophthalmo-acromelic-like phenotype in Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Lines:  EPD0348_1_A01, EPD0348_1_B01, EPD0348_1_C02, EPD0348_1_C03, EPD0348_1_D01, EPD0348_1_E01, EPD0348_1_E02, EPD0348_1_F01, EPD0348_1_F03, EPD0348_1_F04, EPD0348_1_G02, EPD0348_1_H02, EPD0348_1_H03
Germline Transmission:  Earliest citation of germline transmission: J:174198
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 81135318 of Chromosome 12 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 81136165. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)
Generation of the Smoc1tm1a(EUCOMM)Wtsi allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Smoc1 Mutation:  19 strains or lines available
References
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/05/2018
MGI 6.12
The Jackson Laboratory