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Targeted Allele Detail
Symbol: Smoc1tm1a(EUCOMM)Wtsi
Name: SPARC related modular calcium binding 1; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4431709
Synonyms: Smoc1tm1a
Gene: Smoc1  Location: Chr12:81026808-81186414 bp, + strand  Genetic Position: Chr12, 37.28 cM
Ophthalmo-acromelic-like phenotype in Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi mice

Show the 3 phenotype image(s) involving this allele.

Mutant Cell Lines:  EPD0348_1_A01, EPD0348_1_B01, EPD0348_1_C02, EPD0348_1_C03, EPD0348_1_D01, EPD0348_1_E01, EPD0348_1_E02, EPD0348_1_F01, EPD0348_1_F03, EPD0348_1_F04, EPD0348_1_G02, EPD0348_1_H02, EPD0348_1_H03
Germline Transmission:  Earliest citation of germline transmission: J:174198
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 81135318 of Chromosome 12 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 81136165. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:155845, J:173534)
Generation of the Smoc1tm1a(EUCOMM)Wtsi allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Smoc1 Mutation:  19 strains or lines available
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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