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Hiratm1a(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Hiratm1a(EUCOMM)Wtsi
Name: histone cell cycle regulator; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4431679
Gene: Hira  Location: Chr16:18877037-18970309 bp, + strand  Genetic Position: Chr16, 11.69 cM, cytoband A-B1
Mutation
origin
Mutant Cell Lines:  EPD0181_1_A01, EPD0181_1_A03, EPD0181_1_A04, EPD0181_1_A05, EPD0181_1_A06, EPD0181_1_A07, EPD0181_1_A10, EPD0181_1_A11, EPD0181_1_A12, EPD0181_1_B01, EPD0181_1_B03, EPD0181_1_B04, EPD0181_1_B05, EPD0181_1_B08, EPD0181_1_B10, EPD0181_1_B12, EPD0181_1_C01, EPD0181_1_C02, EPD0181_1_C03, EPD0181_1_C07, EPD0181_1_C08, EPD0181_1_C11, EPD0181_1_D06, EPD0181_1_D09, EPD0181_1_D12, EPD0181_1_E01, EPD0181_1_E05, EPD0181_1_E06, EPD0181_1_E07, EPD0181_1_E08, EPD0181_1_E09, EPD0181_1_E12, EPD0181_1_F03, EPD0181_1_F04, EPD0181_1_F05, EPD0181_1_F06, EPD0181_1_F08, EPD0181_1_F09, EPD0181_1_F11, EPD0181_1_F12, EPD0181_1_G03, EPD0181_1_G04, EPD0181_1_G06, EPD0181_1_G12, EPD0181_1_H02, EPD0181_1_H05, EPD0181_1_H06, EPD0181_1_H08, EPD0181_1_H10, EPD0181_1_H12
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt1
 
Mutation detailsThe L1L2_gt1 cassette was inserted at position 18897159 of Chromosome 16 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 18898092. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/aboutkompstrategies. (J:155845, J:173534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Hira Mutation:  58 strains or lines available
References
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory