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Targeted Allele Detail
Symbol: Mier1tm1a(EUCOMM)Wtsi
Name: MEIR1 treanscription regulator; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4431567
Gene: Mier1  Location: Chr4:103114390-103165754 bp, + strand  Genetic Position: Chr4, 47.36 cM, cytoband C6
Mutant Cell Lines:  EPD0027_1_A04, EPD0027_1_A05, EPD0027_1_B04, EPD0027_1_B05, EPD0027_1_B06, EPD0027_1_C04, EPD0027_1_C05, EPD0027_1_C06, EPD0027_1_D06, EPD0027_1_E05, EPD0027_1_E06, EPD0027_1_F04, EPD0027_1_F05, EPD0027_1_G04, EPD0027_1_H04, EPD0027_1_H05, EPD0027_1_H06
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_st1
Mutation detailsThe L1L2_st1 cassette was inserted at position 103147814 of Chromosome 4 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 103148727. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Mier1 Mutation:  18 strains or lines available
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory