Ephb2^tm2.1Jf
Targeted Allele Detail

Summary

• Symbol: Ephb2^tm2.1Jf
• Name: Eph receptor B2; targeted mutation 2.1, Jonas Frisen
• MGI ID: MGI:4431246
• Synonyms: Ephb2^deltaPDZ, Ephb2^deltaVEV994, EphB2^VEV
• Gene: Ephb2 Location: Chr4:136374850-136563299 bp, - strand Genetic Position: Chr4, 69.0 cM, cytoband D-E
• Alliance: Ephb2^tm2.1Jf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157019
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Deletion of codons 992-994 (removing the PDZ binding domain) as well as the insertion of an FRT flanked hygro cassette within exon 17 was accomplished by homologous recombination. The selection cassette has been removed by flp mediated recombination. (J:157019)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ephb2 Mutation: 66 strains or lines available

References

• Original: J:157019 Genander M, et al., Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell. 2009 Nov 13;139(4):679-92
• All: 6 reference(s)