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Targeted Allele Detail
Symbol: Terf1tm2.1Tdl
Name: telomeric repeat binding factor 1; targeted mutation 2.1, Titia de Lange
MGI ID: MGI:4431206
Synonyms: TRF1F
Gene: Terf1  Location: Chr1:15875870-15914276 bp, + strand  Genetic Position: Chr1, 4.88 cM, cytoband E3
Germline Transmission:  Earliest citation of germline transmission: J:157331
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1. Cre mediated recombination removed the neo cassette leaving exon 1 floxed. (J:157331)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Terf1 Mutation:  28 strains or lines available
Original:  J:157331 Sfeir A, et al., Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell. 2009 Jul 10;138(1):90-103
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory