Grhl3^tm1(cre)Cgh
Targeted Allele Detail

Summary

• Symbol: Grhl3^tm1(cre)Cgh
• Name: grainyhead like transcription factor 3; targeted mutation 1, Shaun R Coughlin
• MGI ID: MGI:4430902
• Synonyms: Grhl3^cre
• Gene: Grhl3 Location: Chr4:135269199-135300941 bp, - strand Genetic Position: Chr4, 67.76 cM
• Alliance: Grhl3^tm1(cre)Cgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157446
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Grhl3^tm1(cre)Cgh expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Grhl3 (MGI:2655333)

• Mutation details: Exon 1 was disrupted by the insertion of a cassette containing a cre, IRES, nuclear localization signal, and lacZ in frame with the ATG start site. An frt flanked neomycin cassette was inserted following lacZ. Chimeric males were crossed with females expressing Flp recombinase on a C57BL/6 background in order to excise the neo selection cassette. (J:157446)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Grhl3 (mouse) Summary of all recombinase alleles driven by Grhl3. Comparative matrix view of recombinase activities Alliance mouse Grhl3 gene page

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grhl3 Mutation: 53 strains or lines available

References

• Original: J:157446 Camerer E, et al., Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell. 2010 Jan 19;18(1):25-38
• All: 19 reference(s)