About   Help   FAQ
Fa2htm1.1Hama
Targeted Allele Detail
Nomenclature
Symbol: Fa2htm1.1Hama
Name: fatty acid 2-hydroxylase; targeted mutation 1.1, Hiroko Hama
MGI ID: MGI:4430585
Synonyms: Fa2h-
Gene: Fa2h  Location: Chr8:111345135-111393824 bp, - strand  Genetic Position: Chr8, 57.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171655
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted in intron 4 and an FRT flanked neo cassette and loxP site were inserted in intron 6 via homologous recombination. Cre mediated recombination removed exons 5 and 6 and the neo cassette. Homozygous mice express a shorter mRNA form at levels similar to expression of the full length form in wild-type mice. (J:171655)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fa2h Mutation:  11 strains or lines available
References
Original:  J:171655 Potter KA, et al., Central nervous system dysfunction in a mouse model of Fa2h deficiency. Glia. 2011 Jul;59(7):1009-21
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/15/2018
MGI 6.12
The Jackson Laboratory