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Acacbtm1Dejs
Targeted Allele Detail
Nomenclature
Symbol: Acacbtm1Dejs
Name: acetyl-Coenzyme A carboxylase beta; targeted mutation 1, David James
MGI ID: MGI:4430244
Gene: Acacb  Location: Chr5:114146535-114250761 bp, + strand  Genetic Position: Chr5, 55.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157000
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon12 was flanked with loxP sites and a neomycin cassette was added. Cre-mediated recombination subsequently removed exon 12, the neomycin selection cassette, and caused a frameshift mutation and an early stop codon. Mice were confirmed deficient by western blotting. (J:157000)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acacb Mutation:  54 strains or lines available
References
Original:  J:157000 Hoehn KL, et al., Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metab. 2010 Jan;11(1):70-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory