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Targeted Allele Detail
Symbol: Dnase1l1tm1Dkfz
Name: deoxyribonuclease 1-like 1; targeted mutation 1, German Cancer Research Center
MGI ID: MGI:4430191
Gene: Dnase1l1  Location: ChrX:74273217-74282337 bp, - strand  Genetic Position: ChrX, 37.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:156989
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette has replaced a segment of the gene including exons 3-5; exon 3 contains the ATG translation initiation codon. If splicing occurs between exons 2 and 6, translation from the only in-frame ATG would yield a 60-amino acid (aa) peptide (the full length protein contains 302 aa) that lacks the activity domain. (J:156989)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnase1l1 Mutation:  37 strains or lines available
Original:  J:156989 Krebs I, et al., Targeted mutation of Dnase1l1. MGI Direct Data Submission. 2010;
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory