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Targeted Allele Detail
Symbol: Fgfr2tm2Ewj
Name: fibroblast growth factor receptor 2; targeted mutation 2, Ethylin Wang Jabs
MGI ID: MGI:4430185
Synonyms: Fgfr2P253Rneo
Gene: Fgfr2  Location: Chr7:130162451-133123350 bp, - strand  Genetic Position: Chr7, 73.19 cM
Skeletal abnormalities in Fgfr2tm2Ewj/Fgfr2+ Tg(EIIa-cre)C5379Lmgd/0 mice

Show the 8 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:156940
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Single point mutation
Mutation detailsA C to G transversion results in the amino acid substitution of arginine for proline at position 253 (P253R). A floxed neo cassette was used for selection purposes. (J:158773)
Generation of the Fgfr2tm2Ewj allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:  52 strains or lines available
Original:  J:156940 Aldridge K, et al., Brain phenotypes in two FGFR2 mouse models for Apert syndrome. Dev Dyn. 2010 Jan 13;239(3):987-997
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory