About   Help   FAQ
Fgfr2tm2Ewj
Targeted Allele Detail
Nomenclature
Symbol: Fgfr2tm2Ewj
Name: fibroblast growth factor receptor 2; targeted mutation 2, Ethylin Wang Jabs
MGI ID: MGI:4430185
Synonyms: Fgfr2P253Rneo
Gene: Fgfr2  Location: Chr7:130162451-133123350 bp, - strand  Genetic Position: Chr7, 73.19 cM
Skeletal abnormalities in Fgfr2tm2Ewj/Fgfr2+ Tg(EIIa-cre)C5379Lmgd/0 mice

Show the 8 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156940
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Single point mutation
 
Mutation detailsA C to G transversion results in the amino acid substitution of arginine for proline at position 253 (P253R). A floxed neo cassette was used for selection purposes. (J:158773)
Generation of the Fgfr2tm2Ewj allele
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 23 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:  52 strains or lines available
References
Original:  J:156940 Aldridge K, et al., Brain phenotypes in two FGFR2 mouse models for Apert syndrome. Dev Dyn. 2010 Jan 13;239(3):987-997
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/15/2018
MGI 6.12
The Jackson Laboratory