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Tg(Rho-GUCA1A*Y99C)L53Amd
Transgene Detail
Nomenclature
Symbol: Tg(Rho-GUCA1A*Y99C)L53Amd
Name: transgene insertion L53, Alexander M Dizhoor
MGI ID: MGI:4430086
Synonyms: Y99C GCAP1
Transgene: Tg(Rho-GUCA1A*Y99C)L53Amd  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x DBA/2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Rho-GUCA1A*Y99C)L53Amd expresses 1 gene
 
Mutation detailsThe mouse promoter drives rod and cone-specific expression of the bovine cDNA containing a mutation that results in an amino acid substitution of cysteine for tyrosine at position 99 (Y99C). This mutation is found in human patients with late-onset retinal dystrophy. Several lines were created (L52, L52H, L53, L36, L39, L128, and L52X). Line L53 exhibit a 3- to 4-fold in expression compared to endogenous levels. (J:157063)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:157063 Olshevskaya EV, et al., The Y99C mutation in guanylyl cyclase-activating protein 1 increases intracellular Ca2+ and causes photoreceptor degeneration in transgenic mice. J Neurosci. 2004 Jul 7;24(27):6078-85
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory