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Targeted Allele Detail
Symbol: Ctnnb1tm4.1Wbm
Name: catenin (cadherin associated protein), beta 1; targeted mutation 4.1, Walter Birchmeier
MGI ID: MGI:4429437
Synonyms: Ctnnb1-
Gene: Ctnnb1  Location: Chr9:120929216-120960507 bp, + strand  Genetic Position: Chr9, 72.19 cM
Anterior head defects during embryonic development in ApcMin/Apctm1Tno embryos and rescue of head defects by Ctnnb1tm4.1Wbm/Ctnnb1+

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:156864
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted into the second intron and a loxP-flanked neomycin selection cassette was inserted into the sixth intron. The neomycin cassette was removed by transient expression of Cre recombinase in ES cells prior to the production of chimeric mice, leaving two loxP sites that flank exons 3-6 in the final allele. Exons 3-6 were excised by Cre mediated recombination. (J:69463, J:156864)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctnnb1 Mutation:  32 strains or lines available
Original:  J:156864 Buchert M, et al., Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet. 2010 Jan;6(1):e1000816
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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