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Targeted Allele Detail
Symbol: Porcntm1.1Lcm
Name: porcupine O-acyltransferase; targeted mutation 1.1, Lewis Murtaugh
MGI ID: MGI:4429133
Synonyms: Porcn-2lox, Porcn-lox
Gene: Porcn  Location: ChrX:8193848-8206525 bp, - strand  Genetic Position: ChrX, 3.7 cM
Focal dermal hypoplasia-like phenotypes in Porcntm1.1Lcm/Porcn+ Edil3Tg(Sox2-cre)1Amc/0 embryos

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:173672
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsLoxP sites were introduced into the first and third introns, permitting deletion of exons 2-3 by Cre recombinase. Flp-mediated recombination removed the FRT-flanked neo cassette inserted into the first intron. (J:173672)
Derivation of Porcntm1.1Lcm mutant allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Porcn Mutation:  16 strains or lines available
Original:  J:173672 Barrott JJ, et al., Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome. Proc Natl Acad Sci U S A. 2011 Jul 18;
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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