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Phlpp1tm1.1Saco
Targeted Allele Detail
Nomenclature
Symbol: Phlpp1tm1.1Saco
Name: PH domain and leucine rich repeat protein phosphatase 1; targeted mutation 1.1, Paolo Sassone-Corsi
MGI ID: MGI:4421807
Gene: Phlpp1  Location: Chr1:106171869-106394245 bp, + strand  Genetic Position: Chr1, 49.76 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156530
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4 was floxed and an frt flanked neo cassette was inserted in intron 4 via homologous recombination. Cre mediated recombination then removed exon 4. RT-PCR and western blot analysis confirmed the absence of RNA and protein expression in brains from homozygous mice. (J:156530)
Generation of the Phlpp1tm1Saco and Phlpp1tm1.1Saco alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phlpp1 Mutation:  32 strains or lines available
References
Original:  J:156530 Masubuchi S, et al., Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1642-7
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory