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Targeted Allele Detail
Symbol: Phlpp1tm1.1Saco
Name: PH domain and leucine rich repeat protein phosphatase 1; targeted mutation 1.1, Paolo Sassone-Corsi
MGI ID: MGI:4421807
Gene: Phlpp1  Location: Chr1:106171869-106394245 bp, + strand  Genetic Position: Chr1, 49.76 cM
Germline Transmission:  Earliest citation of germline transmission: J:156530
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 4 was floxed and an frt flanked neo cassette was inserted in intron 4 via homologous recombination. Cre mediated recombination then removed exon 4. RT-PCR and western blot analysis confirmed the absence of RNA and protein expression in brains from homozygous mice. (J:156530)
Generation of the Phlpp1tm1Saco and Phlpp1tm1.1Saco alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phlpp1 Mutation:  32 strains or lines available
Original:  J:156530 Masubuchi S, et al., Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1642-7
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory