About   Help   FAQ
Grntm1Aidi
Targeted Allele Detail
Nomenclature
Symbol: Grntm1Aidi
Name: granulin; targeted mutation 1, Aihao Ding
MGI ID: MGI:4421704
Synonyms: pgrnflox
Gene: Grn  Location: Chr11:102430507-102436809 bp, + strand  Genetic Position: Chr11, 66.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156824
Parent Cell Line:  C2J (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J/J
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and an frt floxed neo cassette with a 3' loxP site was inserted downstream of exon 4. (J:156824)
Generation of the Grntm1Aidi and Grntm1.1Aidi alleles
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grn Mutation:  33 strains or lines available
References
Original:  J:156824 Yin F, et al., Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. J Exp Med. 2010 Jan 18;207(1):117-28, S1-4
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/06/2021
MGI 6.16
The Jackson Laboratory