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Targeted Allele Detail
Symbol: Grntm1Aidi
Name: granulin; targeted mutation 1, Aihao Ding
MGI ID: MGI:4421704
Synonyms: pgrnflox
Gene: Grn  Location: Chr11:102430507-102436809 bp, + strand  Genetic Position: Chr11, 66.29 cM
Germline Transmission:  Earliest citation of germline transmission: J:156824
Parent Cell Line:  C2J (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J/J
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 1 and an frt floxed neo cassette with a 3' loxP site was inserted downstream of exon 4. (J:156824)
Generation of the Grntm1Aidi and Grntm1.1Aidi alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grn Mutation:  33 strains or lines available
Original:  J:156824 Yin F, et al., Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. J Exp Med. 2010 Jan 18;207(1):117-28, S1-4
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory