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Targeted Allele Detail
Symbol: Del(11Sparc-Gpx3)91Anjm
Name: deletion, Chr 11, Andrew N J McKenzie
MGI ID: MGI:4421679
Gene: Del(11Sparc-Gpx3)91Anjm  Location: Chr11:54902453-55420080 bp  Genetic Position: Chr11, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:155870
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Deletion, Insertion
  Del(11Sparc-Gpx3)91Anjm involves 17 genes/genome features (Gm12234, Gpx3, Tnip1 ...) View all
Mutation detailsThis deletion was created by cre mediated recombination of loxP sites within Sparc (created by eliminating exon 6 and replacing it with a Neo-LoxP as well as inserting stop codons in all three reading-frames) and beyond Gpx3 (created by random insertion vector of loxP-Puro cassette). The deletion spans an interval of between 0.7 Mb to 1.5 Mb, between Sparc and Gpx3 and includes Fat2, Gm2a, Anxa6, and Tnip1. (J:155870)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(11Sparc-Gpx3)91Anjm Mutation:  0 strains or lines available
Original:  J:155870 Barlow JL, et al., A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med. 2010 Jan;16(1):59-66
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory