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Del(11Sparc-Gpx3)91Anjm
Targeted Allele Detail
Nomenclature
Symbol: Del(11Sparc-Gpx3)91Anjm
Name: deletion, Chr 11, Andrew N J McKenzie
MGI ID: MGI:4421679
Gene: Del(11Sparc-Gpx3)91Anjm  Location: Chr11:54902453-55420080 bp  Genetic Position: Chr11, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155870
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Deletion, Insertion
  Del(11Sparc-Gpx3)91Anjm involves 17 genes/genome features (Gpx3, Tnip1, Gm12230 ...) View all
 
Mutation detailsThis deletion was created by cre mediated recombination of loxP sites within Sparc (created by eliminating exon 6 and replacing it with a Neo-LoxP as well as inserting stop codons in all three reading-frames) and beyond Gpx3 (created by random insertion vector of loxP-Puro cassette). The deletion spans an interval of between 0.7 Mb to 1.5 Mb, between Sparc and Gpx3 and includes Fat2, Gm2a, Anxa6, and Tnip1. (J:155870)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(11Sparc-Gpx3)91Anjm Mutation:  0 strains or lines available
References
Original:  J:155870 Barlow JL, et al., A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med. 2010 Jan;16(1):59-66
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory