Del(11Sparc-Gpx3)91Anjm
Targeted Allele Detail

Summary

• Symbol: Del(11Sparc-Gpx3)91Anjm
• Name: deletion, Chr 11, Andrew N J McKenzie
• MGI ID: MGI:4421679
• Gene: Del(11Sparc-Gpx3)91Anjm Location: Chr11:54793680-55310906 bp Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155870
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(11Sparc-Gpx3)91Anjm involves 17 genes/genome features (Gm12234, Gpx3, Tnip1 ...) View all
• Mutation details: This deletion was created by cre mediated recombination of loxP sites within Sparc (created by eliminating exon 6 and replacing it with a Neo-LoxP as well as inserting stop codons in all three reading-frames) and beyond Gpx3 (created by random insertion vector of loxP-Puro cassette). The deletion spans an interval of between 0.7 Mb to 1.5 Mb, between Sparc and Gpx3 and includes Fat2, Gm2a, Anxa6, and Tnip1. (J:155870)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(11Sparc-Gpx3)91Anjm Mutation: 0 strains or lines available

References

• Original: J:155870 Barlow JL, et al., A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med. 2010 Jan;16(1):59-66
• All: 1 reference(s)