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Targeted Allele Detail
Symbol: Sparctm1Anjm
Name: secreted acidic cysteine rich glycoprotein; targeted mutation 1, Andrew N J McKenzie
MGI ID: MGI:4421677
Gene: Sparc  Location: Chr11:55394500-55420080 bp, - strand  Genetic Position: Chr11, 33.04 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:155870
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA lox P site and neo cassette were inserted between exons 5 and 7, eliminating exon 6, as well as inserting stop codons into all three frames upstream of the neo. (J:155870)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sparc Mutation:  76 strains or lines available
Original:  J:155870 Barlow JL, et al., A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med. 2010 Jan;16(1):59-66
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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