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Targeted Allele Detail
Symbol: Clocktm1Rep
Name: circadian locomotor output cycles kaput; targeted mutation 1, Steven M Reppert
MGI ID: MGI:4421507
Synonyms: Clockflox, Clocktm1Drw
Gene: Clock  Location: Chr5:76357715-76452639 bp, - strand  Genetic Position: Chr5, 40.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:109634
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed neo cassette containing neomycin resistance and thymidine kinase genes was inserted upstream of exon 5 and a loxp site was inserted downstream of exon 6. Transient cre expression in ES cells removed the neo cassette leaving exons 5 and 6 floxed (J:109634)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Clock Mutation:  71 strains or lines available
Original:  J:109634 Debruyne JP, et al., A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron. 2006 May 4;50(3):465-77
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory