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Tg(Ppp1r2-cre)4127Nkza
Transgene Detail
Nomenclature
Symbol: Tg(Ppp1r2-cre)4127Nkza
Name: transgene insertion 4127, Kazu Nakazawa
MGI ID: MGI:4421503
Synonyms: Cre #4127, Ppp1r2-cre
Transgene: Tg(Ppp1r2-cre)4127Nkza  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6N
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsBAC homologous recombination was used to insert cre cDNA (fused with a nuclear localization signal (NLS) sequence) immediately upstream of the initiation codon of the Ppp1r2 gene in BAC RPCI-24-322B4. The cre cDNA was followed by the bovin growth hormone-derived polyadenylation signal. In one clone, a 12-kb deletion introduced around the initial methionine codon of the apolipoprotein D (Apod) coding sequence, located 50 kb upstream of Ppp1r2, was identified. This clone was used to prevent overexpression of Apod in the brain of transgenic mice. (J:156785)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ppp1r2     Summary of all recombinase alleles driven by Ppp1r2. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:156785 Belforte JE, et al., Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes. Nat Neurosci. 2010 Jan;13(1):76-83
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory