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Targeted Allele Detail
Symbol: Cebpbtm1.1Maka
Name: CCAAT/enhancer binding protein (C/EBP), beta; targeted mutation 1.1, Masato Kasuga
MGI ID: MGI:4421439
Synonyms: Cebpbfl
Gene: Cebpb  Location: Chr2:167688915-167690418 bp, + strand  Genetic Position: Chr2, 87.58 cM
Abnormal glucose and insulin homeostasis in Ins2Akita/Ins2Akita and Ins2Akita/Ins2Akita Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 but not Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 mice.

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:156725
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThe coding exon was floxed. A floxed neo cassette used for selection was removed by cre mediated recombination. (J:156725)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cebpb Mutation:  13 strains or lines available
Original:  J:156725 Matsuda T, et al., Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. J Clin Invest. 2010 Jan;120(1):115-26
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory