Cebpb^tm1.1Maka
Targeted Allele Detail

Summary

• Symbol: Cebpb^tm1.1Maka
• Name: CCAAT/enhancer binding protein beta; targeted mutation 1.1, Masato Kasuga
• MGI ID: MGI:4421439
• Synonyms: Cebpb^fl
• Gene: Cebpb Location: Chr2:167530835-167532338 bp, + strand Genetic Position: Chr2, 87.58 cM
• Alliance: Cebpb^tm1.1Maka page

Abnormal glucose and insulin homeostasis in Ins2^Akita/Ins2^Akita and Ins2^Akita/Ins2^Akita Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 but not Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 mice.

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156725
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The coding exon was floxed. A floxed neo cassette used for selection was removed by cre mediated recombination. (J:156725)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpb Mutation: 23 strains or lines available

References

• Original: J:156725 Matsuda T, et al., Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. J Clin Invest. 2010 Jan;120(1):115-26
• All: 1 reference(s)