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Targeted Allele Detail
Symbol: Bmftm2.1Rjd
Name: BCL2 modifying factor; targeted mutation 2.1, Roger J Davis
MGI ID: MGI:4421179
Synonyms: BmfS74D, BmfSD
Gene: Bmf  Location: Chr2:118528757-118549686 bp, - strand  Genetic Position: Chr2, 59.4 cM, cytoband E5
Germline Transmission:  Earliest citation of germline transmission: J:153652
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA floxed neo cassette was inserted within intron 3, and specific nucleotide mutations in exon 3 were introduced by homologous recombination. Mutation resulted in the JNK protein kinase phosphorylation site (Ser-74) in exon 3 to be substituted with an Asp (S74D). The neo cassette was then excised with Cre mediated recombination leaving a single loxP site in intron 3. (J:153652)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bmf Mutation:  17 strains or lines available
Original:  J:153652 Hubner A, et al., Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo. Mol Cell Biol. 2010 Jan;30(1):98-105
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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