Tg(Thy1-PTGS2)316Kand
Transgene Detail

Summary

• Symbol: Tg(Thy1-PTGS2)316Kand
• Name: transgene insertion 316, Katrin Andreasson
• MGI ID: MGI:4420227
• Synonyms: hCOX-2, Thy-1-COX-2 tg line 316
• Transgene: Tg(Thy1-PTGS2)316Kand Location: unknown
• Alliance: Tg(Thy1-PTGS2)316Kand page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-PTGS2)316Kand expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PTGS2 (5743)

  Ptgs2

  (MGI:97798)

• Mutation details: The transgene construct contains the entire 1.8 kb human COX-2 (PTGS2; prostaglandin-endoperoxide synthase 2 or PGE2) open reading frame sequence inserted into the 8.2 kb Thy-1 expression cassette. This construct was injected into the male pronuclei of C57BL/6J cells. No founder lines were provided in the original reference but lines 300, 303, and 316 were characterized in subsequent publications. (J:72034)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:72034 Andreasson KI, et al., Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice. J Neurosci. 2001 Oct 15;21(20):8198-209
• All: 2 reference(s)