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Acantm1(cre/ERT2)Crm
Targeted Allele Detail
Nomenclature
Symbol: Acantm1(cre/ERT2)Crm
Name: aggrecan; targeted mutation 1, Benoit de Crombrugghe
MGI ID: MGI:4420223
Synonyms: Agc1tm(IRES-creERT2), AgcCre, Agctm(IRES-CreERT-Neo-pgk
Gene: Acan  Location: Chr7:78703231-78764847 bp, + strand  Genetic Position: Chr7, 44.88 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155982
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsIRES-cre/ERT2 and an FRT-flanked PGK-neo selection cassette (in reverse orientation to the target gene) was inserted into the 3' UTR of the Aggrecan gene by homologous recombination in G4 ES cells. The line was established by breeding to C57BL/6 mice. The neo cassette was not removed. (J:155982)
Generation of the Acantm1(cre/ERT2)Crm allele
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Acan     Summary of all recombinase alleles driven by Acan. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acan Mutation:  45 strains or lines available
References
Original:  J:155982 Henry SP, et al., Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage. Genesis. 2009 Dec;47(12):805-14
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory