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Targeted Allele Detail
Symbol: Cox6a1tm1(KOMP)Wtsi
Name: cytochrome c oxidase subunit 6A1; targeted mutation 1, Wellcome Trust Sanger Institute
MGI ID: MGI:4419915
Gene: Cox6a1  Location: Chr5:115345652-115348958 bp, - strand  Genetic Position: Chr5, 56.06 cM
Mutant Cell Lines:  EPD0412_2_A12, EPD0412_2_B11, EPD0412_2_C09, EPD0412_2_C11, EPD0412_2_E09, EPD0412_2_F09, EPD0412_2_F10, EPD0412_2_G12
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
Mutation detailsThe insertion of the L1L2_Bact_P cassette created a deletion of size 3143 starting at position 115348750 and ending at position 115345607 of Chromosome 5 (Genome Build GRCm38). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534, J:230212)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Cox6a1 Mutation:  8 strains or lines available
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory