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Targeted Allele Detail
Symbol: Zc3h14tm1a(KOMP)Wtsi
Name: zinc finger CCCH type containing 14; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4419828
Gene: Zc3h14  Location: Chr12:98746964-98787753 bp, + strand  Genetic Position: Chr12, 49.88 cM, cytoband F1
Mutant Cell Lines:  EPD0366_5_A01, EPD0366_5_A04, EPD0366_5_B01, EPD0366_5_B03, EPD0366_5_B04, EPD0366_5_C03, EPD0366_5_C04, EPD0366_5_D02, EPD0366_5_D03, EPD0366_5_D04, EPD0366_5_E01, EPD0366_5_E02, EPD0366_5_E03, EPD0366_5_E04, EPD0366_5_F01, EPD0366_5_F03, EPD0366_5_F04, EPD0366_5_G02, EPD0366_5_G03, EPD0366_5_G04, EPD0366_5_H02, EPD0366_5_H04
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 98783160 of Chromosome 12 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 98783990. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Zc3h14 Mutation:  7 strains or lines available
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory