Irf7^{tm1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Irf7^{tm1(KOMP)Wtsi}
• Name: interferon regulatory factor 7; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4419590
• Gene: Irf7 Location: Chr7:140843096-140846412 bp, - strand Genetic Position: Chr7, 86.57 cM, cytoband F5
• Alliance: Irf7^{tm1(KOMP)Wtsi} page
• IMPC: Irf7 gene page

Mutation origin

• Mutant Cell Lines: EPD0376_1_C05, EPD0376_1_C06, EPD0376_1_D05, EPD0376_1_D06, EPD0376_1_E05, EPD0376_1_E06, EPD0376_1_F05, EPD0376_1_F06, EPD0376_1_H05, EPD0376_1_H06
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 2111 starting at position 140843354 and ending at position 140845465 of Chromosome 7 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 1 line available
• Carrying any Irf7 Mutation: 23 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 6 reference(s)