Dio1tm1(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Dio1tm1(KOMP)Wtsi |
Name: |
deiodinase, iodothyronine, type I; targeted mutation 1, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:4419442 |
Gene: |
Dio1 Location: Chr4:107148662-107164365 bp, - strand Genetic Position: Chr4, 50.18 cM
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IMPC: |
Dio1 gene page |
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Mutant Cell Lines: |
EPD0390_3_A09, EPD0390_3_A11, EPD0390_3_B09, EPD0390_3_B11, EPD0390_3_B12, EPD0390_3_C10, EPD0390_3_D09, EPD0390_3_D10, EPD0390_3_E09, EPD0390_3_E10, EPD0390_3_F09, EPD0390_3_F10, EPD0390_3_F11, EPD0390_3_F12, EPD0390_3_G09, EPD0390_3_G10, EPD0390_3_G12, EPD0390_3_H12 |
Germline Transmission: |
Unknown
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
Vector: L1L2_Bact_P
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Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 4332 starting at position 107150805 and ending at position 107155137 of Chromosome 4 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site.
(J:148605, J:173534)
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Original: |
J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009; |
All: |
2 reference(s) |
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