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Lsm2tm1(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Lsm2tm1(KOMP)Wtsi
Name: LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated; targeted mutation 1, Wellcome Trust Sanger Institute
MGI ID: MGI:4419407
Gene: Lsm2  Location: Chr17:34981862-34985891 bp, + strand  Genetic Position: Chr17, 18.52 cM
Mutation
origin
Mutant Cell Lines:  EPD0416_2_B12, EPD0416_2_C09, EPD0416_2_C10, EPD0416_2_D12, EPD0416_2_E10, EPD0416_2_H10, EPD0416_2_H11
Germline Transmission:  Unknown
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe insertion of the L1L2_Bact_P cassette created a deletion of size 2767 starting at position 34982597 and ending at position 34985364 of Chromosome 17 (Genome Build GRCm38). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 2 lines available
Carrying any Lsm2 Mutation:  18 strains or lines available
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory