Treml4^{tm1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Treml4^{tm1(KOMP)Wtsi}
• Name: triggering receptor expressed on myeloid cells-like 4; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4419374
• Gene: Treml4 Location: Chr17:48571323-48582388 bp, + strand Genetic Position: Chr17, 23.99 cM
• Alliance: Treml4^{tm1(KOMP)Wtsi} page
• IMPC: Treml4 gene page

Mutation origin

• Mutant Cell Lines: EPD0374_4_A05, EPD0374_4_A07, EPD0374_4_A08, EPD0374_4_B07, EPD0374_4_C05, EPD0374_4_C07, EPD0374_4_C08, EPD0374_4_D05, EPD0374_4_E06, EPD0374_4_E08, EPD0374_4_F05, EPD0374_4_G05, EPD0374_4_G08, EPD0374_4_H05, EPD0374_4_H06
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 5169 starting at position 48571635 and ending at position 48576804 of Chromosome 17 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Treml4 Mutation: 17 strains or lines available

Notes

Cell line EPD0374_4_C05 was/was not successfully used to make chimeric mice. Germline transmission was/was not accomplished. J:231858

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 4 reference(s)