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Isl1tm3Sev
Targeted Allele Detail
Nomenclature
Symbol: Isl1tm3Sev
Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 3, Sylvia Evans
MGI ID: MGI:4418967
Synonyms: isl1-nLacZ
Gene: Isl1  Location: Chr13:116298281-116309689 bp, - strand  Genetic Position: Chr13, 64.87 cM, cytoband D2.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156167
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector containing a loxP-flanked nuclear lacZ (nLacZ) reporter gene, followed by a humanized renilla GFP (hrGFP) sequence and an FRT-flanked neomycin resistance gene, was inserted into a SalI site of the Isl1 locus, replacing a short segment of coding sequence including the endogenous ATG start codon. (J:156167)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 203 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Isl1 Mutation:  19 strains or lines available
References
Original:  J:156167 Sun Y, et al., Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol. 2007 Apr 1;304(1):286-96
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory