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Transgene Detail
Symbol: Tg(Camk2a-tTA)1Stl
Name: transgene insertion 1, Susumu Tonegawa
MGI ID: MGI:4418554
Synonyms: alphaCamKII-loxP-STOP-loxP-tTA, Tg2
Transgene: Tg(Camk2a-tTA)1Stl  Location: unknown  
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
Mutation detailsThe transgene construct contained the tetracycline transactivator (tTA) coding sequence downstream of a loxP-STOP-loxP fragement. This was inserted downstream of the alpha-CamKII (Camk2a) promoter in the final construct. Pronuclei of fertilized C57BL/6 eggs were injected with the purified linearized construct. A founder line 1 was established by backcrossing the founder with C57BL/6 mice. (J:131852)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:131852 Nakashiba T, et al., Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning. Science. 2008 Feb 29;319(5867):1260-4
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory