Tg(CD68-rtTA2S*M2)3Mpil
Transgene Detail
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Symbol: |
Tg(CD68-rtTA2S*M2)3Mpil |
Name: |
transgene insertion 3, Manoj M Pillai |
MGI ID: |
MGI:4418488 |
Synonyms: |
CD68-MP3, CD68-rtTA, CD68-rtTA-M2 |
Transgene: |
Tg(CD68-rtTA2S*M2)3Mpil Location: unknown Genetic Position: Chr1, Syntenic
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Alliance: |
Tg(CD68-rtTA2S*M2)3Mpil page
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Transgene Type: |
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Transgenic (Transactivator) |
Mutation: |
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Insertion
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Mutation details: The CD68-rtTA-M2 transgene was designed with a 2.9 kb promoter sequence from the human CD68 gene followed by a 83 bp fist intron (IVIS), a modified reverse tetracycline-regulated transactivator (rtTA) gene (from plasmid pUHRT-62-1), and bovine growth hormone polyA tail. This 4.5 kb transgene was microinjected into the male pronuclei of two cell (C57BL/6 x CBA) mouse zygotes. Founder line 3 (CD68-MP3) was established and backcrossed to C57BL/6 mice for at least 11 generations. The insertion site has been mapped to Chr 1.
(J:154457)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:154457 Pillai MM, et al., Inducible transgenes under the control of the hCD68 promoter identifies mouse macrophages with a distribution that differs from the F4/80 - and CSF-1R-expressing populations. Exp Hematol. 2009 Dec;37(12):1387-92 |
All: |
5 reference(s) |
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