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Kcnh3tm1Akmi
Targeted Allele Detail
Nomenclature
Symbol: Kcnh3tm1Akmi
Name: potassium voltage-gated channel, subfamily H (eag-related), member 3; targeted mutation 1, Akira Miyake
MGI ID: MGI:4418359
Synonyms: BEC1 KO
Gene: Kcnh3  Location: Chr15:99224976-99242817 bp, + strand  Genetic Position: Chr15, 56.08 cM, cytoband F3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155749
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced exon 1 and its start codon. RT-PCR and Western blot analysis indicated the near absence of mRNA and the absence of protein respectively. (J:155749)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnh3 Mutation:  18 strains or lines available
References
Original:  J:155749 Miyake A, et al., Disruption of the ether-a-go-go K+ channel gene BEC1/KCNH3 enhances cognitive function. J Neurosci. 2009 Nov 18;29(46):14637-45
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory