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Aqp12tm1Rai
Targeted Allele Detail
Nomenclature
Symbol: Aqp12tm1Rai
Name: aquaporin 12; targeted mutation 1, Tatemitsu Rai
MGI ID: MGI:4418194
Gene: Aqp12  Location: Chr1:93006334-93012269 bp, + strand  Genetic Position: Chr1, 46.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155920
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3 were replaced with a 1.8 kb neomycin cassette. Both Northern blot analysis an RT-PCR demonstrate the absence of transcript. (J:155920)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp12 Mutation:  12 strains or lines available
References
Original:  J:155920 Ohta E, et al., Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis. Am J Physiol Cell Physiol. 2009 Dec;297(6):C1368-78
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory