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Gt(ROSA)26Sortm1(RNU6-RNAi:Trpv1)Thch
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(RNU6-RNAi:Trpv1)Thch
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Thomas Christoph
MGI ID: MGI:4418115
Synonyms: TRPV1 shRNAtg
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132700
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Knockdown, RMCE-ready)
Mutation:    Insertion
  Gt(ROSA)26Sortm1(RNU6-RNAi:Trpv1)Thch involves 1 genes/genome features (Trpv1) View all
 
Mutation detailsThe siRNA VsiR1 driven by the human U6 (RNU6) promoter was inserted into the locus using recombinase mediated cassette exchange (RMCE). Decreased expression of Trpv1 was confirmed by RT-PCR analysis and reduced protein expression was confirmed by a lack of receptor agonist binding. (J:132700)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  504 strains or lines available
References
Original:  J:132700 Christoph T, et al., Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice. Mol Cell Neurosci. 2008 Mar;37(3):579-89
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory