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Tg(KRT14-COL7A1*)1Shzu
Transgene Detail
Nomenclature
Symbol: Tg(KRT14-COL7A1*)1Shzu
Name: transgene insertion 1, Hiroshi Shimizu
MGI ID: MGI:4417882
Synonyms: COL7K14-deltah+
Transgene: Tg(KRT14-COL7A1*)1Shzu  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(KRT14-COL7A1*)1Shzu expresses 1 gene
 
Mutation detailsThe human promoter was used to drive epidermis-specific expression of the human cDNA with the c.7528delG mutation. This mutation creates a premature stop codon 18 bp downstream of the end of the collagenous domain. Several lines were created with most robust expressing line was selected as the representative line. No line numbers given. (J:155326)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:155326 Ito K, et al., Keratinocyte-/fibroblast-targeted rescue of Col7a1-disrupted mice and generation of an exact dystrophic epidermolysis bullosa model using a human COL7A1 mutation. Am J Pathol. 2009 Dec;175(6):2508-17
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory