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Dnaic1tm1.1Leo
Targeted Allele Detail
Nomenclature
Symbol: Dnaic1tm1.1Leo
Name: dynein, axonemal, intermediate chain 1; targeted mutation 1.1, Lawrence E Ostrowski
MGI ID: MGI:4415595
Synonyms: Dnaicflox
Gene: Dnaic1  Location: Chr4:41569775-41638158 bp, + strand  Genetic Position: Chr4, 21.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155730
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 17 and 18 were floxed. The frt flanked neo cassette used for selection purposes was removed by flp mediated recombination leaving a single frt site. (J:155730)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnaic1 Mutation:  31 strains or lines available
References
Original:  J:155730 Ostrowski LE, et al., Conditional deletion of dnaic1 in a murine model of primary ciliary dyskinesia causes chronic rhinosinusitis. Am J Respir Cell Mol Biol. 2010 Jul;43(1):55-63
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory