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Targeted Allele Detail
Symbol: Parp11tm1(KOMP)Vlcg
Name: poly (ADP-ribose) polymerase family, member 11; targeted mutation 1, Velocigene
MGI ID: MGI:4415414
Synonyms: Parp11-
Gene: Parp11  Location: Chr6:127446840-127494261 bp, + strand  Genetic Position: Chr6, 62.39 cM
Mutant Cell Lines:  12032A-A10, 12032A-B7, 12032A-D4, 12032A-F12
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  VGB6 (ES Cell)
Strain of Origin:  C57BL/6NTac
Project Collection: KOMP-Regeneron
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: ZEN-Ub1
Mutation detailsThe insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 21037bp between positions 127420726-127441762 of Chromosome 6 (Genome Build37). This insertion results in the removal of coding exons 4-8 and allows expression of the reporter gene beta-galactosidase under the control of the endogenous promoter. Semi-quantitative RT-PCR analysis of total RNA confirmed the absence of transcripts in kidney, brain, lung and testis tissues from homozygous mutant mice. (J:136110, J:221906)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 2 lines available
Carrying any Parp11 Mutation:  19 strains or lines available
Original:  J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory