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Targeted Allele Detail
Symbol: Cavin2tm1(KOMP)Vlcg
Name: caveolae associated 2; targeted mutation 1, Velocigene
MGI ID: MGI:4415387
Gene: Cavin2  Location: Chr1:51289126-51302960 bp, + strand  Genetic Position: Chr1, 26.13 cM
Mutant Cell Lines:  11065A-A12, 11065A-B1, 11065A-C2, 11065A-H7
Germline Transmission:  Earliest citation of germline transmission: J:205741
Parent Cell Line:  VGB6 (ES Cell)
Strain of Origin:  C57BL/6NTac
Project Collection: KOMP-Regeneron
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: ZEN-Ub1
Mutation detailsThe insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 12123bp between positions 51346233-51358355 of Chromosome 1 (Genome Build37). The cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression in the lung, heart, fat, skeletal muscle, brain and liver. (J:136110, J:205741)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 2 lines available
Carrying any Cavin2 Mutation:  17 strains or lines available
Cell line 11065A-H7 was successfully used to make chimeric mice. Germline transmission was accomplished. J:205741
Original:  J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008;
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory