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Tg(Tcra3a.56,Tcrb3a.56)1Dorf
Transgene Detail
Nomenclature
Symbol: Tg(Tcra3a.56,Tcrb3a.56)1Dorf
Name: transgene insertion 1, Martin E Dorf
MGI ID: MGI:4415295
Transgene: Tg(Tcra3a.56,Tcrb3a.56)1Dorf  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Tcra3a.56,Tcrb3a.56)1Dorf expresses 2 genes
 
Mutation detailsThis transgene expresses the re-arranged TCRalpha and TCRbeta chains derived from the encephalitogenic CD4+ TH1 cell clone 3a.56, which is specific for the 26-mer encoded by myelin basic protein (MBP) exon 2. (J:109724)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Mice that express this transgene develop experimental autoimmune encephalomyelitis (EAE) upon immunization with myelin basic protein peptide.
References
Original:  J:155727 Abromson-Leeman S, et al., Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNgamma but have a spectrum of IL-17 profiles. J Neuroimmunol. 2009 Oct 30;215(1-2):10-24
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory