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Nefmtm1Dwc
Targeted Allele Detail
Nomenclature
Symbol: Nefmtm1Dwc
Name: neurofilament, medium polypeptide; targeted mutation 1, Don W Cleveland
MGI ID: MGI:4415254
Synonyms: NF-MS-A
Gene: Nefm  Location: Chr14:68119545-68125004 bp, - strand  Genetic Position: Chr14, 35.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155659
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsAll the codons corresponding to the serines in the lysine-serine-proline (KSP) repeats in exon 3 were modified to code for alanines. An Nefl 3' region and neo cassette were added downstream of exon 3. (J:155659)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nefm Mutation:  21 strains or lines available
References
Original:  J:155659 Garcia ML, et al., Phosphorylation of highly conserved neurofilament medium KSP repeats is not required for myelin-dependent radial axonal growth. J Neurosci. 2009 Feb 4;29(5):1277-84
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory