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Tg(S100A8-cre,-EGFP)1Ilw
Transgene Detail
Nomenclature
Symbol: Tg(S100A8-cre,-EGFP)1Ilw
Name: transgene insertion 1, Irving L Weissman
MGI ID: MGI:4415239
Synonyms: MRP8-Cre-ires/GFP, Mrp8creTg, Tg(S100A8-cre,-GFP)1Empa, Tg(S100A8-cre,-GFP)1Ilw
Transgene: Tg(S100A8-cre,-EGFP)1Ilw  Location: unknown  Genetic Position: Chr5, Syntenic
Transgene
origin
Strain of Origin:  (C57BL/6 x C3H)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutations:    Insertion, Intergenic deletion
  Tg(S100A8-cre,-EGFP)1Ilw involves 2 genes/genome features (Ap1s1, Serpine1) View all
 
Mutation detailsThe human promoter drives expression of cre followed by an IRES sequence and EGFP in granulocytes and a fraction of myelomonocytic progenitors. Two founders were generated (no line information given). a A single copy of the transgene integrated at a single site on chromosome 5 (137,042,580-137,086,690; mouse mm10). This insertion leads to a 44 kb deletion of the host genome, resulting in complete deletion of the Serpine1 gene and partial deletion of the Ap1s1 gene. (J:94778, J:323640)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: S100A8 (human) Summary of all recombinase alleles driven by S100A8.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:94778 Passegue E, et al., JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell. 2004 Oct 29;119(3):431-43
All:  62 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/28/2022
MGI 6.20
The Jackson Laboratory