Ghr^tm1.1Jero
Targeted Allele Detail

Summary

• Symbol: Ghr^tm1.1Jero
• Name: growth hormone receptor; targeted mutation 1.1, Jennifer Rowland
• MGI ID: MGI:4414833
• Synonyms: GHR^Box1-
• Gene: Ghr Location: Chr15:3347237-3612834 bp, - strand Genetic Position: Chr15, 1.84 cM
• Alliance: Ghr^tm1.1Jero page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155335
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 9 was replaced with one in which nucleotide substitutions result in amino acid substitutions of the prolines with alanines within the Box1 domain (LILPPVPVPKIK to LILAAVAVAKIK). A floxed neo cassette used for selection purposes was removed by cre mediated recombination. (J:155335)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ghr Mutation: 49 strains or lines available

References

• Original: J:155335 Barclay JL, et al., In vivo targeting of the growth hormone receptor (GHR) Box1 sequence demonstrates that the GHR does not signal exclusively through JAK2. Mol Endocrinol. 2010 Jan;24(1):204-17
• All: 2 reference(s)