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Targeted Allele Detail
Symbol: Clcn7tm3.1Tjj
Name: chloride channel, voltage-sensitive 7; targeted mutation 3.1, Thomas J Jentsch
MGI ID: MGI:4413670
Synonyms: Clcn7lox
Gene: Clcn7  Location: Chr17:25133391-25162104 bp, + strand  Genetic Position: Chr17, 12.53 cM, cytoband A3.3
Germline Transmission:  Earliest citation of germline transmission: J:155176
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was upstream of exon 12 and a floxed neo cassette was inserted downstream of exon 13. Cre mediated recombination removed the neo cassette leaving exons 12 and 13 floxed. (J:155176)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clcn7 Mutation:  19 strains or lines available
Original:  J:155176 Wartosch L, et al., Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7. FASEB J. 2009 Dec;23(12):4056-68
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.04
The Jackson Laboratory